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Endocrine Abstracts

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ea0067o64 | Oral Presentations | EYES2019

Conservative management of diabetic foot ulceration complicated by underlying osteomyelitis

Dorman E , Salem V , Valabhji J , Bravis V

Objective: To describe the clinical presentation of forefoot and midfoot diabetic foot ulcers (DFUs) complicated by osteomyelitis and their outcomes with conservative management in a multi-disciplinary care environment and determine predictors of ulcer healing.Methods: This is a retrospective study of all consecutive cases of DFUs complicated by osteomyelitis presenting to our multi-disciplinary diabetes foot clinic between 1st January and 30th June 2016...
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ea0019oc4 | Young Endocrinologist prize session | SFEBES2009

Kisspeptin potently increases reproductive hormone release in women with hypothalamic amenorrhoea: a potential novel therapy for infertility

Jayasena CN , Chaudhri OB , Nijher GK , Murphy KG , Ranger A , Lim A , Patel D , Mehta A , Todd C , Ramachandran R , Salem V , Stamp GW , Donaldson M , Ghatei MA , Bloom SR , Dhillo WS

Background: Kisspeptin is a critical regulator of normal reproductive function. In humans inactivating mutations of the kisspeptin receptor GPR54 cause hypogonadotrophic hypogonadism and pubertal failure. Activating mutations of GPR54 cause precocious puberty. Hypothalamic amenorrhoea (HA) accounts for over 30% of cases of amenorrhoea in women of reproductive age. Current treatments have limited success rates and side effects. In rodent models of HA hypothalamic KISS1 expressi...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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